An IRON-clad Connection between Aging Organelles.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31978339.
- Also identified by DOI 10.1016/j.cell.2019.12.037.
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Abstract
Lysosome (vacuole) and mitochondria decline interdependently during aging through an unclear mechanism. In this issue of Cell, Hughes et al. (2020) show that defective vacuole-mediated cysteine compartmentalization in aging yeast leads to iron limitation and mitochondrial dysfunction.
Medical subject headings
- Cysteine
- Iron