Potassium channels in control of renal function.
Level V
Where this comes from
- Record sourced from PubMed, PMID 31980072.
- Also identified by DOI 10.1016/j.kint.2019.10.029.
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Abstract
Potassium channels are important to control membrane potential and drive epithelial transport processes. In this issue of Kidney International, Bignon et al. report the role of the Kir4.2 K<sup>+</sup>-channel, localized at the basolateral membrane of proximal tubules, in the reabsorption of bicarbonate and the modulation of renal ammoniagenesis. The findings have implications for our understanding of how the kidney reacts to hypokalemia, an acid load, and the metabolic acidosis of patients with advanced stages of chronic kidney disease.
Medical subject headings
- Hypokalemia
- Potassium