Uncovering the etiology of CINAC, a complex and mysterious renal syndrome: the invaluable role of histopathology and electron microscopy.
other · Level V
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- Record sourced from PubMed, PMID 31980074.
- Also identified by DOI 10.1016/j.kint.2019.10.005.
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Abstract
Chronic interstitial nephritis in agricultural communities (CINAC) is a progressive form of tubulointerstitial nephritis affecting agricultural workers in different parts of the world. Its underlying etiology is not known, although a study by Vervaet and coworkers in this issue of Kidney International provides strong evidence that CINAC is a lysosomal tubulopathy induced by toxin exposure. Key to this important discovery is a thorough morphologic analysis of kidney tissue, including ultrastructural as well as histopathologic examination.
Medical subject headings
- Nephritis, Interstitial
- Renal Insufficiency