Reciprocal Regulation of HSD11B1 and HSD11B2 Predicts Glucocorticoid Sensitivity in Childhood Acute Lymphoblastic Leukemia.
Where this comes from
- Record sourced from PubMed, PMID 31987650.
- Also identified by DOI 10.1016/j.jpeds.2019.12.054.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
There are few biomarkers to predict efficacy of glucocorticoid treatment in childhood acute lymphoblastic leukemia (ALL) at diagnosis. Here, we demonstrate reciprocal regulation of 11beta-hydroxysteroid dehydrogenase (11β-HSD), may predict the apoptotic response of ALL to glucocorticoid treatment. Our data may be useful to refine glucocorticoid treatment, to retain benefit while minimizing side effects.
Medical subject headings
- 11-beta-Hydroxysteroid Dehydrogenase Type 1
- 11-beta-Hydroxysteroid Dehydrogenase Type 2
- Dexamethasone
- Glucocorticoids
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Prednisolone