Deep Sequencing Reveals Occult Mansonellosis Coinfections in Residents From the Brazilian Amazon Village of São Gabriel da Cachoeira.

Crainey, James Lee; Costa, Carlos Henrique Aguiar; de Oliveira Leles, Lorena Ferreira; Ribeiro da Silva, Túllio Romão; de Aquino Narzetti, Luiz Henrique; Serra Dos Santos, Yago Vinícius; Costa Conteville, Liliane; Costa Pessoa, Felipe Arley et al. · Clin Infect Dis · 2020

cross_sectional · Level IV

Where this comes from

Abstract

Mansonella ozzardi and Mansonella perstans infections both cause mansonellosis but are usually treated differently. Using a real-time polymerase chain reaction assay and deep sequencing, we reveal the presence of mansonellosis coinfections that were undetectable by standard diagnostic methods. Our results confirm mansonellosis coinfections and have important implications for the disease's treatment and diagnosis.

Medical subject headings