Paper #17: Early Onset Scoliosis within the 22q11.2 Deletion Syndrome (22q11.2DS).
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 31997193.
- Also identified by DOI 10.1016/j.jspd.2017.09.020.
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Abstract
22q11.2DS is the most common microdeletion syndrome. It is characterized by a wide phenotypic variability, including scoliosis. This is the first epidemiological study that shows that the prevalence of early onset scoliosis within this vulnerable group of patients is around 40%. A congenital heart defect (CHD) irrespective of surgery was an independent risk factor, with an Odd's Ratio of 12.09.