Paper #16: HIF-1α critical to Somitogenesis and interacts with the Notch pathway leading to vertebral malformations.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 31997194.
- Also identified by DOI 10.1016/j.jspd.2017.09.019.
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Abstract
HIF-1α is critical to somitogenesis. Lack of HIF-1α disrupts the Notch signaling pathway which leads to vertebral malformations seen in congenital scoliosis.