The combination of asymmetric hydrogenation of olefins and direct reductive amination.
basic_science · Level V
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- Record sourced from PubMed, PMID 32001706.
- Also identified by DOI 10.1038/s41467-020-14475-x and PMC identifier 6992772.
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Abstract
Asymmetric hydrogenation (AH) and direct reductive amination (DRA) are both efficient transformations frequently utilized in industry. Here we combine the asymmetric hydrogenation of prochiral olefins and direct reductive amination of aldehydes in one step using hydrogen gas as the common reductant and a rhodium-Segphos complex as the catalyst. With this strategy, the efficiency for the synthesis of the corresponding chiral amino compounds is significantly improved. The practical application of this synthetic approach is demonstrated by the facile synthesis of chiral 3-phenyltetrahydroquinoline and 3-benzylindoline compounds.