PET/CT Imaging with an <sup>18</sup>F-Labeled Galactodendritic Unit in a Galectin-1-Overexpressing Orthotopic Bladder Cancer Model.
Where this comes from
- Record sourced from PubMed, PMID 32005776.
- Also identified by DOI 10.2967/jnumed.119.236430 and PMC identifier 7456169.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Galectins are carbohydrate-binding proteins overexpressed in bladder cancer (BCa) cells. Dendritic galactose moieties have a high affinity for galectin-expressing tumor cells. We radiolabeled a dendritic galactose carbohydrate with <sup>18</sup>F (<sup>18</sup>F-labeled galactodendritic unit <b>4</b>) and examined its potential in imaging urothelial malignancies. <b>Methods:</b> The <sup>18</sup>F-labeled first-generation galactodendritic unit <b>4</b> was obtained from its tosylate precursor. We conducted <i>in vivo</i> studies in a galectin-expressing UMUC3 orthotopic BCa model to determine the ability of <sup>18</sup>F-labeled galactodendritic unit <b>4</b> to image BCa. <b>Results:</b> Intravesical administration of <sup>18</sup>F-labeled galactodendritic unit <b>4</b> allowed specific accumulation of the carbohydrate radiotracer in galectin-1-overexpressing UMUC3 orthotopic tumors when imaged with PET. The <sup>18</sup>F-labeled galactodendritic unit <b>4</b> was not found to accumulate in nontumor murine bladders. <b>Conclusion:</b> The <sup>18</sup>F-labeled galactodendritic unit <b>4</b> and similar analogs may be clinically relevant and exploitable for PET imaging of galectin-1-overexpressing bladder tumors.
Medical subject headings
- Fluorine Radioisotopes
- Galactose
- Galectin 1
- Gene Expression Regulation, Neoplastic
- Positron Emission Tomography Computed Tomography
- Urinary Bladder Neoplasms