Fibrinogen induces neural stem cell differentiation into astrocytes in the subventricular zone via BMP signaling.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32005867.
- Also identified by DOI 10.1038/s41467-020-14466-y and PMC identifier 6994610.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Neural stem/progenitor cells (NSPCs) originating from the subventricular zone (SVZ) contribute to brain repair during CNS disease. The microenvironment within the SVZ stem cell niche controls NSPC fate. However, extracellular factors within the niche that trigger astrogliogenesis over neurogenesis during CNS disease are unclear. Here, we show that blood-derived fibrinogen is enriched in the SVZ niche following distant cortical brain injury in mice. Fibrinogen inhibited neuronal differentiation in SVZ and hippocampal NSPCs while promoting astrogenesis via activation of the BMP receptor signaling pathway. Genetic and pharmacologic depletion of fibrinogen reduced astrocyte formation within the SVZ after cortical injury, reducing the contribution of SVZ-derived reactive astrocytes to lesion scar formation. We propose that fibrinogen is a regulator of NSPC-derived astrogenesis from the SVZ niche via BMP receptor signaling pathway following injury.
Medical subject headings
- Astrocytes
- Bone Morphogenetic Protein Receptors, Type I
- Fibrinogen
- Lateral Ventricles
- Neural Stem Cells
- Neurogenesis