Plasmonic nucleotide hybridization chip for attomolar detection: localized gold and tagged core/shell nanomaterials.
basic_science · Level V
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- Record sourced from PubMed, PMID 32009138.
- Also identified by DOI 10.1039/c9lc01150a.
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Abstract
We report a large amplification of surface plasmon signals for a double hybridization microarray chip assembly that bridges localized gold and detection probe-carrying-core/shell Fe<sub>3</sub>O<sub>4</sub>@Au nanoparticles for detection of as low as 80 aM miRNA-155 marker in solution. The plasmonic wavelength match of the gold shell with surface localized gold nanoparticles and the additional scattering band of the core/shell material in resonance with the incident 800 nm light source are the underlying factors for the observed remarkable analyte signal at ultra-low (10<sup>-18</sup> order) concentrations.
Medical subject headings
- Gold
- Metal Nanoparticles