Pharmacogenomics: An evolving clinical tool for precision medicine.
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- Record sourced from PubMed, PMID 32015062.
- Also identified by DOI 10.3949/ccjm.87a.19073.
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Abstract
Pharmacogenomics, ie, the study of how an individual's genomic profile influences his or her response to drugs, has emerged as a clinical tool to optimize drug therapy. Certain variants in some genes increase the risk of severe, life-threatening adverse effects from certain drugs. Integrating pharmacogenomics into clinical practice to assist in drug selection and dosing has the potential to improve the outcomes of treatment, reduce the risk of drug-induced morbidity and death, and be cost-effective.
Medical subject headings
- Codeine
- Cytochrome P-450 CYP2D6
- Pharmacogenetics
- Pharmacogenomic Variants
- Precision Medicine