Double Trouble: Concomitant <i>RB1</i> and <i>BRCA2</i> Depletion Evokes Aggressive Phenotypes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32019859.
- Also identified by DOI 10.1158/1078-0432.CCR-19-4033 and PMC identifier 7165038.
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Abstract
Coordinate single- or two copy loss of the <i>BRCA2</i>/<i>RB1</i> tumor suppressor genes, which reside in close chromosomal proximity, were found to be associated with aggressive prostate cancer and therapeutic resistance. Modeling these events and analyses of human cancers suggest that dual depletion of <i>BRCA2/RB1</i> may represent a distinct subtype of disease.<i>See related article by Chakraborty et al., p. 2047</i>.
Medical subject headings
- Genes, BRCA2
- Prostatic Neoplasms