Tranexamic acid is toxic on human chondrocytes, <i>in vitro</i>.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32021047.
- Also identified by DOI 10.1016/j.jor.2019.12.008 and PMC identifier 6994788.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The aim of this study was to examine toxic effects of tranexamic acid (TXA) on the viability of human chondrocytes. Our hypothesis was that TXA damages human chondrocytes. Chondrocytes were cultured from donated human knee joints. TXA was added to these cultures. Toxicity were analyzed by using LDH und XTT Elisa assays, light microscopy and fluorescence microscopy. The results show that TXA damages human chondrocytes <i>in vitro</i>. We cannot recommend the use of TXA in hemiarthroplasty of the hip or unicompartmental knee arthroplasty in higher concentrations.