Alcohol Makes Its Epigenetic Marks.
Level V
Where this comes from
- Record sourced from PubMed, PMID 32023443.
- Also identified by DOI 10.1016/j.cmet.2020.01.008 and PMC identifier 7162615.
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Abstract
The toxic effects of alcohol consumption are dependent upon its metabolism in the liver to downstream metabolites: acetaldehyde, acetate, and acetyl-CoA. Recently, in Nature, Mews et al. (2019) have discovered that acetyl-CoA derived from alcohol plays an important epigenetic role in regulating ethanol's effects on the brain through histone acetylation.
Medical subject headings
- Ethanol
- Histones