Glucose Starvation Blocks Translation at Multiple Levels.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32023445.
- Also identified by DOI 10.1016/j.cmet.2020.01.005.
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Abstract
Deficiency of glucose, even under sufficient amino acid supply, turns off translation and promotes catabolic processes to aid cell survival. A recent report by Yoon et al. (2020) shows that glucose is required for the full activity of the leucyl-tRNA synthetase LARS1 and maintains mTORC1 function via LARS1 to enhance translation. Glucose starvation abolishes both effects via phosphorylation of LARS1 by the AMPK-ULK1 signaling pathway. This study supports the idea that glucose starvation inhibits translation at multiple levels.
Medical subject headings
- Amino Acyl-tRNA Synthetases
- Starvation