Butler enables rapid cloud-based analysis of thousands of human genomes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32024987.
- Also identified by DOI 10.1038/s41587-019-0360-3 and PMC identifier 7062635.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner.
Medical subject headings
- Computational Biology
- Genome, Human
- Neoplasms