Calcium sulphate mixed with antibiotics does not decrease efficacy against <i>Cutibacterium acnes</i> (formerly <i>Propionibacterium acnes</i>), <i>in vitro</i> study.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32025121.
- Also identified by DOI 10.1016/j.jor.2019.11.028 and PMC identifier 6997646.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
This study explored the <i>in vitro</i> efficacy of antibiotics mixed with calcium sulfate (ACS) against <i>Cutibacterium acnes (C. acnes).</i> <i>C. acnes</i> isolates from orthopaedic infection sites were tested for antimicrobial susceptibility with ACS. Minimal inhibitory concentrations (MIC) were determined with a gradient diffusion method (Etest® strips). When tested with Etest®, all 22 isolates were susceptible to penicillin, ceftriaxone, vancomycin, and two were resistant to clindamycin (MICs of 4 and 8 mg/L). Penicillin and rifampin had the largest inhibition zone diameters. Antibiotics retained activity against <i>C. acnes</i> when mixed with calcium sulfate.