Keeping Fibrotic Responses in Contractile Tissues at Bay: The Plot t(Hic1)ens.

Kim, Johnny; Braun, Thomas · Cell Stem Cell · 2020

editorial · Level V

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Abstract

Two recent papers in Cell Stem Cell by Soliman et al. (2020) and Scott et al. (2019) explore the contributions of mesenchymal progenitor cells to fibrosis in heart and skeletal muscle. They find tissue-dependent roles for a subpopulation of mesenchymal progenitors expressing Hic1 with varied differentiation capacities and pathophysiologic contributions.

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