Detection of Variants With Reduced Baloxavir Marboxil Susceptibility After Treatment of Children With Influenza A During the 2018-2019 Influenza Season.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 32034420.
- Also identified by DOI 10.1093/infdis/jiaa061.
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Abstract
During the 2018-2019 influenza seasons, we detected reduced baloxavir marboxil (baloxavir) susceptible variants with I38S or I38T amino acid substitutions on the PA subunit of influenza virus ribonucleic acid polymerase in 7 of 18 baloxavi-treated children and found that virus titer rebounded in some of these children with variants. We also found fever durations to be similar between patients with or without the variants, but the patients with variants shed the virus 3 days longer and took longer to improve clinical symptoms than those without variants. The emergence of these variants should be monitored during future influenza seasons.
Medical subject headings
- Antiviral Agents
- Dibenzothiepins
- Drug Resistance, Viral
- Influenza A Virus, H3N2 Subtype
- Influenza, Human
- Morpholines
- Pyridones
- Triazines