Methplotlib: analysis of modified nucleotides from nanopore sequencing.
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- Record sourced from PubMed, PMID 32053166.
- Also identified by DOI 10.1093/bioinformatics/btaa093 and PMC identifier 7214038.
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Abstract
Modified nucleotides play a crucial role in gene expression regulation. Here, we describe methplotlib, a tool developed for the visualization of modified nucleotides detected from Oxford Nanopore Technologies sequencing platforms, together with additional scripts for statistical analysis of allele-specific modification within-subjects and differential modification frequency across subjects. The methplotlib command-line tool is written in Python3, is compatible with Linux, Mac OS and the MS Windows 10 Subsystem for Linux and released under the MIT license. The source code can be found at https://github.com/wdecoster/methplotlib and can be installed from PyPI and bioconda. Our repository includes test data, and the tool is continuously tested at travis-ci.com. Supplementary data are available at Bioinformatics online.
Medical subject headings
- Nanopore Sequencing
- Nanopores