Transmission of NS5A-Inhibitor Resistance-Associated Substitutions Among Men Who Have Sex With Men Recently Infected with Hepatitis C Virus Genotype 1a.

Popping, Stephanie; Verwijs, Rosanne; Cuypers, Lize; Claassen, Mark A; van den Berk, Guido E; De Weggheleire, Anja; Arends, Joop E; Boerekamps, Anne et al. · Clin Infect Dis · 2020

cross_sectional · Level IV

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Abstract

The transmission of direct-acting antiviral resistance-associated substitutions (RAS) could hamper hepatitis C virus (HCV) cure rates and elimination efforts. A phylogenetic analysis of 87 men who have sex with men recently infected with HCV genotype 1a placed one-third (28/87) in a large cluster, in which 96% harbored NS5A M28V RAS.

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