SPsimSeq: semi-parametric simulation of bulk and single-cell RNA-sequencing data.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32065619.
- Also identified by DOI 10.1093/bioinformatics/btaa105 and PMC identifier 7214028.
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Abstract
SPsimSeq is a semi-parametric simulation method to generate bulk and single-cell RNA-sequencing data. It is designed to simulate gene expression data with maximal retention of the characteristics of real data. It is reasonably flexible to accommodate a wide range of experimental scenarios, including different sample sizes, biological signals (differential expression) and confounding batch effects. The R package and associated documentation is available from https://github.com/CenterForStatistics-UGent/SPsimSeq. Supplementary data are available at Bioinformatics online.
Medical subject headings
- RNA
- Software