<i>Plasmodium</i>-infected erythrocytes induce secretion of IGFBP7 to form type II rosettes and escape phagocytosis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32066522.
- Also identified by DOI 10.7554/eLife.51546 and PMC identifier 7048393.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
In malaria, rosetting is described as a phenomenon where an infected erythrocyte (IRBC) is attached to uninfected erythrocytes (URBC). In some studies, rosetting has been associated with malaria pathogenesis. Here, we have identified a new type of rosetting. Using a step-by-step approach, we identified IGFBP7, a protein secreted by monocytes in response to parasite stimulation, as a rosette-stimulator for <i>Plasmodium falciparum</i>- and <i>P. vivax</i>-IRBC. IGFBP7-mediated rosette-stimulation was rapid yet reversible. Unlike type I rosetting that involves direct interaction of rosetting ligands on IRBC and receptors on URBC, the IGFBP7-mediated, type II rosetting requires two additional serum factors, namely von Willebrand factor and thrombospondin-1. These two factors interact with IGFBP7 to mediate rosette formation by the IRBC. Importantly, the IGFBP7-induced type II rosetting hampers phagocytosis of IRBC by host phagocytes.
Medical subject headings
- Erythrocytes
- Insulin-Like Growth Factor Binding Proteins
- Phagocytosis
- Plasmodium falciparum
- Plasmodium vivax