The Nucleotide-Free State of the Cannabinoid CB2/Gi Complex.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32084338.
- Also identified by DOI 10.1016/j.cell.2020.01.034.
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Abstract
In this issue of Cell, two papers report agonist-bound cryo-EM structures of the cannabinoid receptor, CB2, in complex with Gi. Importantly, beyond providing information that could help distinguish CB2 ligand binding from CB1, these structures support the existence of a nucleotide-free state during G-protein signaling.
Medical subject headings
- Cannabinoids
- Receptor, Cannabinoid, CB2