Magnesium as a Janus-faced inhibitor of calcification.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 32087884.
- Also identified by DOI 10.1016/j.kint.2019.11.035.
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Abstract
Vascular calcification is a life-threatening complication in patients with chronic kidney disease. Magnesium is a potent inhibitor of calcification and attracting attention as a new therapeutic candidate. ter Braake and colleagues demonstrate that magnesium supplementation strikingly prevents vascular calcification in Klotho knockout mice. However, these mice also show osteomalacia, indicating that magnesium has a Janus face. Maximizing the beneficial effects of magnesium without causing bone mineralization defects is an important next challenge.
Medical subject headings
- Renal Insufficiency, Chronic
- Vascular Calcification