Glycolipid-mediated basophil activation in alpha-gal allergy.

Iweala, Onyinye I; Choudhary, Shailesh K; Addison, Claire T; Batty, Cole J; Kapita, Camille M; Amelio, Claire; Schuyler, Alexander J; Deng, Shenglou et al. · J Allergy Clin Immunol · 2020

Level V

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Abstract

Alpha-gal-containing glycolipids activate basophils sensitized with plasma from alpha-gal allergic subjects in an IgE-dependent manner suggesting a role for glycolipid in the effector phase of IgE-mediated food allergy.

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