Long non-coding RNA ATB promotes human non-small cell lung cancer proliferation and metastasis by suppressing miR-141-3p.
basic_science · Level V
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- Record sourced from PubMed, PMID 32092085.
- Also identified by DOI 10.1371/journal.pone.0229118 and PMC identifier 7039450.
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Abstract
Long noncoding RNA activated by transforming growth factor-β (lncRNA-ATB) plays a critical role in progression of several cancers. In this study, lncRNA-ATB was significantly up-regulated in NSCLC tissues and cell lines, and high lncRNA-ATB expression indicated poor prognosis. Knockdown of lncRNA-ATB suppressed NSCLC cell growth, colony formation, migration, invasion and reversed epithelial-mesenchymal transition. In vivo study showed that silencing lncRNA-ATB inhibited tumor growth. Further mechanism studies demonstrated that lncRNA-ATB was a target of miR-141-3p. MiR-141-3p expression was negatively related to lncRNA-ATB expression in NSCLC tissues. These results suggested that inhibiting lncRNA-ATB might be an approach for NSCLC treatment.
Medical subject headings
- Carcinoma, Non-Small-Cell Lung
- Gene Expression Regulation, Neoplastic
- Lung Neoplasms
- MicroRNAs
- RNA, Long Noncoding