Antibacterial activity of <i>Syzygium aromaticum</i> (clove) against uropathogens producing ESBL, MBL, and AmpC beta-lactamase: Are we close to getting a new antibacterial agent?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32110587.
- Also identified by DOI 10.4103/jfmpc.jfmpc_908_19 and PMC identifier 7014883.
- Licence recorded as CC BY-NC-SA.
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Abstract
The present study was done to access the antibacterial activity of clove (<i>Syzygium aromaticum</i>) against extended-spectrum beta-lactamase (ESBL), metallo-beta-lactamase (MBL), and AmpC beta-lactamase-producing gram-negative bacteria causing urinary tract infection. A total of 221 gram-negative uropathogens were isolated and screened for beta-lactamase (ESBL, MBL, and AmpC) production and further tested against ethanolic extract of clove (<i>S. aromaticum</i>) for its antibacterial activity. Clove was effective against all gram-negative isolates but the best antibacterial activity was shown against <i>Proteus</i> species with 19 mm zone of inhibition, 0.39 mg/ml minimum inhibitory concentration (MIC) and 0.19 mg/ml minimum bactericidal concentration (MBC). Clove extract showed different antibacterial potential against all gram-negative uropathogens. Clove activity for particular strain was found to be similar between isolates producing beta-lactamase and non beta-lactamase.