Pathways towards human immunodeficiency virus elimination.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 32114397.
- Also identified by DOI 10.1016/j.ebiom.2020.102667 and PMC identifier 7047153.
- Licence recorded as CC BY-NC-ND.
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Abstract
Antiretroviral therapy (ART) suppresses human immunodeficiency virus (HIV) infection. Research seeking to transform viral suppression into elimination has generated novel immune, chemical and molecular antiviral agents. However, none, to date, have excised latent integrated proviral DNA or removed infected cells from infected persons. These efforts included, but are not limited to, broadly neutralizing antibodies, "shock" and "kill" latency-reversing agents, innate immune regulators, and sequential long-acting antiretroviral nanoformulated prodrugs and CRISPR-Cas9 gene editing. While, the latter, enabled the complete excision of latent HIV-1 from the host genome success was so far limited. We contend that improvements in antiretroviral delivery, potency, agent specificity, or combinatorial therapies can provide a pathway towards complete HIV elimination.
Medical subject headings
- Disease Eradication
- HIV Infections