Association of catechol-O-methyltranferase 472G>A (Val158Met) polymorphism with susceptibility to fibromyalgia syndrome.
case_control · Level III
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- Record sourced from PubMed, PMID 32127730.
- Also identified by DOI 10.1016/j.jor.2020.01.013 and PMC identifier 7042409.
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Abstract
Several lines of research have suggested that the 472G > A (Val158Met) polymorphism at Catechol-O-methyltranferase (COMT) gene is implicated in the pathophysiology of FMS. Here, we have evaluated the association of COMT 472G > A polymorphism with risk of FMS. In this study 250 patients with FMS and 250 healthy controls were evaluated for COMT 472G > A polymorphism by RFLP-PCR assay. There were no significant differences in the allele and genotype frequencies of COMT 472G > A polymorphism between FMS cases and healthy controls. Our results suggested that the COMT 472G > A polymorphism may not be risk factor for development of FMS.