<i>In vitro</i> and <i>in vivo</i> degradation behavior of Mg-2Sr-Ca and Mg-2Sr-Zn alloys.
basic_science · Level V
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- Record sourced from PubMed, PMID 32128466.
- Also identified by DOI 10.1016/j.bioactmat.2020.02.014 and PMC identifier 7044521.
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Abstract
Magnesium alloys with integration of degradability and good mechanical performance are desired for orthopedic implants. In this paper, Mg-2Sr-Ca and Mg-2Sr-Zn alloys were prepared and the degradation as well as the bone response were investigated. Compared with the binary Mg-2Sr alloys, the addition of Ca and Zn improved the <i>in vitro</i> and <i>in vivo</i> corrosion resistance. Mg-2Sr-Ca and Mg-2Sr-Zn alloys exhibited more uniform corrosion and maintained the configuration of the implants 4 weeks post-implantation. The <i>in vivo</i> corrosion rates were 0.85 mm/yr for Mg-2Sr-Zn and 1.10 mm/yr for Mg-2Sr-Ca in comparison with 1.37 mm/yr for Mg-2Sr. The <i>in vitro</i> cell tests indicated that Mg-2Sr-Ca and Mg-2Sr-Zn alloys exhibited higher MG63 cell viability than Mg-2Sr alloy. Furthermore, these two alloys can promote the mineralization and new bone formation without inducing any significant adverse effects and this sound osteogenic properties suggest its attractive clinical potential.