Identification of scavenger receptor B1 as the airway microfold cell receptor for <i>Mycobacterium tuberculosis</i>.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32134383.
- Also identified by DOI 10.7554/eLife.52551 and PMC identifier 7065847.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
<i>Mycobacterium tuberculosis</i> (Mtb) can enter the body through multiple routes, including via specialized transcytotic cells called microfold cells (M cell). However, the mechanistic basis for M cell entry remains undefined. Here, we show that M cell transcytosis depends on the Mtb Type VII secretion machine and its major virulence factor EsxA. We identify scavenger receptor B1 (SR-B1) as an EsxA receptor on airway M cells. SR-B1 is required for Mtb binding to and translocation across M cells in mouse and human tissue. Together, our data demonstrate a previously undescribed role for Mtb EsxA in mucosal invasion and identify SR-B1 as the airway M cell receptor for Mtb.
Medical subject headings
- Mycobacterium tuberculosis
- Scavenger Receptors, Class B