Animal Models of Congenital Cytomegalovirus Transmission: Implications for Vaccine Development.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32134481.
- Also identified by DOI 10.1093/infdis/jiz484 and PMC identifier 7057791.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Although cytomegaloviruses (CMVs) are species-specific, the study of nonhuman CMVs in animal models can help to inform and direct research aimed at developing a human CMV (HCMV) vaccine. Because the driving force behind the development of HCMV vaccines is to prevent congenital infection, the animal model in question must be one in which vertical transmission of virus occurs to the fetus. Fortunately, two such animal models-the rhesus macaque CMV and guinea pig CMV-are characterized by congenital infection. Hence, each model can be evaluated in "proof-of-concept" studies of preconception vaccination aimed at blocking transplacental transmission. This review focuses on similarities and differences in the respective model systems, and it discusses key insights from each model germane to the study of HCMV vaccines.
Medical subject headings
- Cytomegalovirus
- Cytomegalovirus Infections
- Host-Pathogen Interactions
- Infectious Disease Transmission, Vertical