Chemotherapy Induces Cancer-Fighting B Cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32142652.
- Also identified by DOI 10.1016/j.cell.2020.02.046.
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Abstract
Tumor-infiltrating B cells are heterogeneous, and their roles in tumor immunity are controversial. In this issue of Cell, Lu and colleagues demonstrate that chemotherapy-induced complement signals promote the generation of ICOSL<sup>+</sup>B cells, which enhance tumor-specific T cell responses.
Medical subject headings
- Antineoplastic Agents
- Neoplasms