Too Much Tau in Interneurons Impairs Adult Hippocampal Neurogenesis in Alzheimer's Disease.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32142656.
- Also identified by DOI 10.1016/j.stem.2020.02.004.
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Abstract
Understanding why adult hippocampal neurogenesis (AHN) is impaired in Alzheimer's disease (AD) is essential for unravelling its role in pathogenesis. In this issue of Cell Stem Cell, Zheng et al. (2020) report that human tau accumulation in dentate gyrus GABAergic interneurons disrupts AHN and strengthening GABAergic signaling restores AHN and improves cognition in an AD mouse model.
Medical subject headings
- Alzheimer Disease