Divide and Rule: Mitochondrial Fission Regulates Quiescence in Hematopoietic Stem Cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32142657.
- Also identified by DOI 10.1016/j.stem.2020.02.009.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Hematopoietic stem cells (HSCs) remain quiescent to preserve long-term integrity. In this issue of Cell Stem Cell, Hinge et al. (2020) and Liang et al. (2020) demonstrate that HSCs achieve this by regulating mitochondrial fission and lysosomal activity, suppressing glucose uptake, and maintaining healthy punctate mitochondria with low metabolic activity.
Medical subject headings
- Hematopoietic Stem Cells
- Mitochondrial Dynamics