Young and Restless: Expansion of Donor-Origin Mutant HSCs after Transplantation.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 32142660.
- Also identified by DOI 10.1016/j.stem.2020.01.022.
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Abstract
In a study of young adults chosen as unrelated hematopoietic stem cell donors for patients with hematological malignancies, leukemia-associated mutations were detectable in cells from 44% of donors. Donor-origin mutant clones engrafted in recipients and expanded during the first 100 days after transplant, but donor-derived leukemia was not observed.
Medical subject headings
- Hematologic Neoplasms
- Hematopoietic Stem Cell Transplantation