Boosting Cytotoxic Antibodies against Cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32142673.
- Also identified by DOI 10.1016/j.cell.2020.02.025.
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Abstract
Monoclonal antibodies (mAbs) targeting antigens expressed at the surface of tumor cells are widely used for cancer control in clinics, but these treatments need to be improved. Chew et al. show how an old drug, prochlorperazine, could be repurposed to enhance the efficacy of anti-tumor mAbs by increasing the cell-surface expression of tumor antigens.
Medical subject headings
- Antibody-Dependent Cell Cytotoxicity
- Neoplasms