Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32165541.
- Also identified by DOI 10.1073/pnas.2002589117 and PMC identifier 7132130.
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Abstract
A novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused a large respiratory outbreak in Wuhan, China in December 2019, is currently spreading across many countries globally. Here, we show that a TMPRSS2-expressing VeroE6 cell line is highly susceptible to SARS-CoV-2 infection, making it useful for isolating and propagating SARS-CoV-2. Our results reveal that, in common with SARS- and Middle East respiratory syndrome-CoV, SARS-CoV-2 infection is enhanced by TMPRSS2.
Medical subject headings
- Betacoronavirus
- Coronavirus Infections
- Pneumonia, Viral
- Serine Endopeptidases