Terminating G-Protein Coupling: Structural Snapshots of GPCR-β-Arrestin Complexes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32169216.
- Also identified by DOI 10.1016/j.cell.2020.02.047 and PMC identifier 7115862.
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Abstract
β-arrestins (βarrs) play multifaceted roles in the signaling and regulation of G-protein-coupled receptors (GPCRs) including their desensitization and endocytosis. Recently determined cryo-EM structures of two different GPCRs in complex with βarr1 provide the first glimpse of GPCR-βarr engagement and a structural framework to understand their interaction.
Medical subject headings
- Receptors, G-Protein-Coupled
- beta-Arrestins