Colloidal forming of macroporous calcium pyrophosphate bioceramics in 3D-printed molds.
basic_science · Level V
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- Record sourced from PubMed, PMID 32181416.
- Also identified by DOI 10.1016/j.bioactmat.2020.02.013 and PMC identifier 7063111.
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Abstract
A technique for colloidal forming of Ca<sub>2</sub>P<sub>2</sub>O<sub>7</sub> macroporous bioceramics, based on low-pressure injection molding (LPIM) of a glycerol-water slip containing Ca<sub>2</sub>P<sub>2</sub>O<sub>7</sub> and Ca(Н<sub>2</sub>PO<sub>4</sub>)<sub>2</sub> into a plastic mold fabricated via FDM 3D-printing, was proposed. Chemical reaction between the solid phases of the water containing slip - Ca<sub>2</sub>P<sub>2</sub>O<sub>7</sub> and Ca(Н<sub>2</sub>PO<sub>4</sub>)<sub>2</sub>, resulting in brushite (CaHPO<sub>4</sub>·2H<sub>2</sub>O) formation, led to consolidation of the casting and preserved its complex architecture in the course of mold burning-out. Macroporous ceramics of Kelvin structure (70% macropores with the sizes from 2 up to 4 mm), based on a pre-defined composition with 10 wt% Ca(PO<sub>3</sub>)<sub>2</sub> and sintered in liquid-phase regime, demonstrated a compressive strength of 1.4 ± 0.1 MPa at a density of 22 ± 2%. <i>In vitro</i> tests on bioactivity in SBF solution, as well as on resorption of the ceramics in model solution of citric acid, were carried out.