Host-Range Shift Between Emerging P[8]-4 Rotavirus and Common P[8] and P[4] Strains.
other · Level V
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- Record sourced from PubMed, PMID 32188998.
- Also identified by DOI 10.1093/infdis/jiaa122.
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Abstract
In Tunisia, we observed that rotavirus P[8]-3 and P[4] strains in young children with gastroenteritis associate with secretor histo-blood group phenotype. In contrast, the emerging P[8]-4 strain, representing 10% of cases, was exclusively found in nonsecretor patients. Unlike VP8* from P[8]-3 and P[4] strains, the P[8]-4 VP8* protein attached to glycans from saliva samples regardless of the donor's secretor status. Interestingly, a high frequency of FUT2 enzyme deficiency (nonsecretor phenotype) was observed in the population. This may allow cocirculation of P[8]-3 and P[8]-4 strains in secretor and nonsecretor children, respectively.
Medical subject headings
- Fucosyltransferases
- Host Specificity
- RNA-Binding Proteins
- Rotavirus
- Rotavirus Infections
- Viral Nonstructural Proteins