Repair, Removal, and Shutdown: It All Hinges on RNA Polymerase II Ubiquitylation.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 32200798.
- Also identified by DOI 10.1016/j.cell.2020.02.053.
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Abstract
Two papers, by Nakazawa and Vidaković, show how ubiquitylation of a single lysine residue in RNA polymerase II serves as a master switch to regulate transcription, RNA polymerase II degradation, and transcription-coupled nucleotide excision repair in response to DNA damage.
Medical subject headings
- RNA Polymerase II
- Transcription, Genetic