Nature's remedy to phosphate woes: calciprotein particles regulate systemic mineral metabolism.
Where this comes from
- Record sourced from PubMed, PMID 32200857.
- Also identified by DOI 10.1016/j.kint.2019.12.018.
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Abstract
Calciprotein particles, colloidal complexes of calcium phosphate and plasma protein fetuin-A, have emerged as mediators of multiple biological effects attributed to phosphate. A new study postulates that circulating calciprotein particles, not phosphate, regulate the production of the major bone-derived phosphatonin, fibroblast growth factor-23. The signaling events coupling calciprotein particles sensing in bone to fibroblast growth factor-23 secretion remain to be established.
Medical subject headings
- Fibroblast Growth Factors
- Phosphates