Not all HLA epitope mismatches are equal.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 32200859.
- Also identified by DOI 10.1016/j.kint.2019.12.017.
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Abstract
The future of HLA matching in solid organ transplantation lies in epitope matching. The article by Sapir-Pichhadze et al. provides indirect evidence that there is a difference in immunogenicity between antibody-verified versus non-verified eplets. However, this difference was less clear for HLA class II, showing the need for additional efforts to identify truly immunogenic HLA class II epitope mismatches.
Medical subject headings
- Kidney Transplantation
- Organ Transplantation