Anti-CRISPR protein applications: natural brakes for CRISPR-Cas technologies.
review · Level V
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- Record sourced from PubMed, PMID 32203383.
- Also identified by DOI 10.1038/s41592-020-0771-6 and PMC identifier 8510557.
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Abstract
Clustered, regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) genes, a diverse family of prokaryotic adaptive immune systems, have emerged as a biotechnological tool and therapeutic. The discovery of protein inhibitors of CRISPR-Cas systems, called anti-CRISPR (Acr) proteins, enables the development of more controllable and precise CRISPR-Cas tools. Here we discuss applications of Acr proteins for post-translational control of CRISPR-Cas systems in prokaryotic and mammalian cells, organisms and ecosystems.
Medical subject headings
- CRISPR-Associated Proteins
- CRISPR-Cas Systems
- Enzyme Inhibitors
- Gene Editing
- Gene Expression Regulation