TwisTranscripT: stochastic simulation of the transcription-supercoiling coupling.
basic_science · Level V
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- Record sourced from PubMed, PMID 32232442.
- Also identified by DOI 10.1093/bioinformatics/btaa221.
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Abstract
Transcription and DNA supercoiling are involved in a complex, dynamical and non-linear coupling that results from the basal interaction between DNA and RNA polymerase. We present the first software to simulate this coupling, applicable to a wide range of bacterial organisms. TwisTranscripT allows quantifying its contribution in global transcriptional regulation, and provides a mechanistic basis for the widely observed, evolutionarily conserved and currently unexplained co-regulation of adjacent operons that might play an important role in genome evolution. TwisTranscripT is freely available at https://github.com/sammeyer2017/TwisTranscripT. It is implemented in Python3 and supported on MacOS X, Linux and Windows.
Medical subject headings
- Operon
- Software