Impact of GPCR Structures on Drug Discovery.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 32243800.
- Also identified by DOI 10.1016/j.cell.2020.03.003.
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Abstract
Structures of 70 unique G protein-coupled receptors (GPCRs) have been determined, with over 370 structures in total bound to different ligands and the receptors in various conformational states. Structure-based drug design has been applied to an increasing number of GPCR targets over the past decade and now a few of these drug candidates have entered clinical trials. Given the length of time required for a drug to reach the market, there are no documented examples of licensed drugs being developed with the aid of a structure, but this is likely to change as current efforts come to fruition.
Medical subject headings
- Drug Design
- Drug Discovery
- Receptors, G-Protein-Coupled