Plasticity in Motion: Shape-Shifting Lgr5<sup>-</sup>Cells Initiate Colorectal Cancer Metastasis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 32243803.
- Also identified by DOI 10.1016/j.stem.2020.03.007 and PMC identifier 7295070.
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Abstract
In this issue of Cell Stem Cell, Fumagalli et al. (2020) employ intravital microscopy of colorectal cancer organoid xenografts to investigate the cell of origin of metastases. While tumor-initiating cells are Lgr5<sup>+</sup>, most disseminated cancer cells are Lgr5<sup>-</sup> and seed liver metastases in which Lgr5<sup>+</sup> cells then appear, showing that bidirectional plasticity of phenotypic states drives metastasis.
Medical subject headings
- Colorectal Neoplasms
- Liver Neoplasms